I am a Yale Chemistry PhD in Jorgensen lab. Our lab works on computational-aided drug design in collaboration with in-house experimental synthesis. The early-stage drug design process usually refers to the initial de novo design and virtual screening for lead generation and the following free energy perturbation (FEP) for lead optimization. My research focus is mainly on protein/nucleic force field development and FEP calculation and algorithm development using Molecular Dynamics (MD) and Monte Carlo (MC) simulation. While the force field development lays the foundation of how we describe protein-ligand systems, the simulation methodology development helps us better evaluation the system with given parameter. I have also been working on small molecule property prediction as a side project, which has been posted on this website. All of the above work aims at providing experimental guidance and thus increasing the drug development efficiency.

I was born and raised in Hangzhou, China. It is a city that I always feel attatched to, although I no longer had chance to live there ever since I went college. My path goes from Hangzhou to Shanghai to HongKong and now in New Haven. I see myself learning and adapting, and I am very excited that I will be graduating soon and start to give back. My life-long goal is to make impact to society in a way that changes people's life style or living standards. My favorate tech gaint is Elon Musk, not only because he has tons of ideas and always make them happen, but also his ultimate concern for the wellness of people regardless of who they are. My favorate writers and critics are Lu Xun and Qian Zhongshu. They are both so talented that they always see through people's mind and never lack the courage to tell the truth. I hope I can stick to my goal as time goes.

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